CONTACT IGENEX

Home » Stores » A & M Phlebotomy

AT IGENEX, OUR PRIORITY IS TO MAKE YOUR EXPERIENCE AS CONVENIENT AS POSSIBLE

We Provide a Personalized Path to Help Answer Your Questions

We give you a variety of avenues to get your questions answered quickly from our website.

Do you prefer a human touch? We pride ourselves in making sure that we deliver personalized service with our friendly and knowledgeable staff.

US: (800) 832-3200
International: +1 (650) 424-1191
Email: customerservice@igenex.com

We can help answer questions about the tests we offer, and provide your physician with your result status and a general interpretation of your test results. Only your physician can help you determine which tests to order, and only your physician will be able to provide you with a full analysis of your condition and test results.

OUR LOCATION

556 Gibraltar Dr.
Milpitas, CA 95035, USA

Get in Touch

If you are a physician and would like to learn more about IGeneX or our tick-borne disease testing products, let us know by completing the form below or calling us at 1-800-832-3200. If you are a patient, please do not use this form. Send an email to customerservice@igenex.com or call us at 1-800-832-3200.

We look for more and detect more, no matter when you were exposed

Home » Stores » A & M Phlebotomy

WHY IGENEX IS DIFFERENT

Dedicated R&D

We have a dedicated research and development team of tick-borne disease experts who are relentlessly focused and committed to developing the most precise and effective diagnostic tests for Lyme disease, Tick-Borne Relapsing Fever, and other tick-borne diseases.

– First to identify Borrelia burgdorferi in ticks in California
– First to identify Babesia in New York, Switzerland, and Australia, using our exclusive patented FISH technology

More Comprehensive Testing

We test for more relevant strains of tick-borne pathogens than any other lab, even those pathogens that exhibit Lyme-like symptoms but may be due to a different tick-borne disease and require different treatment paths.

It is important to test for co-infections. Nearly 1 in 4 ticks infected with the Lyme Disease pathogen carry more than one pathogen. That means nearly 25% of patients will not be diagnosed if the patient is tested only for Lyme disease.

Superior Testing Criteria

We developed our in-house testing criteria for Lyme disease and other tick-borne diseases based on decades of evidence and validation studies. Most labs use Lyme disease testing criteria developed in 1994 when much less was known about the disease and its pathogens.

IGeneX has developed several industry-leading tests. Our ImmunoBlot test has a sensitivity rate that is nearly double that of the standard two-tier testing protocol.

Cutting Edge Technologies

We arm our talented scientists with the most cutting-edge technology available to help enable them to find new solutions that challenge the status quo of testing for Lyme and associated tick-borne diseases. This positions us at the forefront of providing the most comprehensive testing possible to aid physicians in diagnosis.

– First to introduce Relapsing Fever Western Blot testing

– First to introduce comprehensive Lyme ImmunoBlot and TBRF ImmunoBlot testing

We are part of the Lyme Community

Lyme disease is the most well-known tick-borne illness and one of the fastest-growing infectious diseases in the United States. It has now been detected in all 50 US States.

IGeneX is deeply dedicated to physician education around Lyme. We are committed partners with Lyme experts and Lyme groups, including ILADS, Bay Area Lyme Foundation, and the Liv Lyme Foundation. IGeneX is also fully CLIA/CMS certified.

Better Detection

IGeneX tests are based on the latest findings of Lyme disease and other tick-borne illnesses to provide the most complete and accurate results for diagnostic purposes. We test for more species than any other lab.

IGeneX offers a broad range of individual tests and panels for all tick-borne diseases. Physicians are encouraged to test their patients using a panel approach, which is a combination of direct and indirect test methodologies that detect multiple tick-borne diseases.

IGeneX ImmunoBlots Are Superior Lyme Disease Tests

Lyme disease has become increasingly challenging to diagnose, making accurate and reliable testing even more essential to inform and support physician diagnoses. The two-tier ELISA/Western Blot testing recommended by the CDC uses result criteria developed in 1994 when far less was known about Lyme disease. These tests don’t provide physicians with a complete picture for accurate diagnosis.

IGeneX ImmunoBlots use recombinant proteins to detect Lyme IgM and IgG antibodies to more B. burgdorferi sensu lato species than the current Western Blot does. Prepared from two strains of B. burgdorferi, the IGeneX ImmunoBlot produces a higher sensitivity and the most comprehensive testing for Lyme disease antibodies in patient serum samples.

Lyme ImmunoBlot IgM

IgM antibodies are the earliest to appear in response to a patient’s exposure to the disease.

IGeneX Specific Proteins (Band-kDA):

23kDa, 31kDa, 34kDa, 39kDa, and 41kDa

IGeneX Result Criteria:

Positive Result:
Combination of any two or more of the above bands

Negative Result:
Any profile that does not meet positive criteria

CDC recommended Specific Proteins (Band-kDA):

23kDa, 39kDa, and 41kDa

CDC Result Criteria:

Positive Result:
Combination of two or more of the above bands

Negative Result:
Any profile that does not meet positive criteria

Lyme ImmunoBlot IgG

Lyme IgG antibodies are produced four-to-six weeks following infection and can persist for years.

IGeneX Specific Proteins (Band-kDA):

23kDa, 31kDa, 34kDa 39kDa, 41kDa, and 93kDa

IGeneX Result Criteria:

Positive Result:
Combination of any two or more of the above bands

Negative Result:
Any profile that does not meet positive criteria

CDC recommended Specific Proteins (Band-kDA):

18kDa, 23kDa, 28kDa, 30kDa. 39kDa, 41kDa, 45kDa, 58kDa, 66kDa, and 93kDa

CDC Result Criteria:

Positive Result:
Combination of five or more of the above bands

Negative Result:
Any profile that does not meet positive criteria

The ImmunoBlot test for Lyme disease has a sensitivity greater than 93%, whereas the ELISA and Western Blot two-tier testing protocol recommended by the CDC has a sensitivity of only 57.6%.

Sources:

The Accuracy of Diagnostic Tests for Lyme Disease in Humans, A Systematic Review and Meta-Analysis of North American Research. PLoS ONE 11(12): e0168613.

Pilot Study of Immunoblots with Recombinant Borrelia burgdorferi Antigens for Laboratory Diagnosis of Lyme Disease

Licensing & Accreditation

IGeneX is licensed in all 50 states because we are CLIA certified. Some states require a separate license. Click a state below to view license.

If you suspect, get yourself checked.

IGeneX Tick-Borne tests are the most complete and accurate tests available.

Home » Stores » A & M Phlebotomy

URINE COLLECTION KIT

The Urine Collection Kit is compatible with all tests that require urine and is another option to test for lyme disease and tick-borne illnesses. We also offer a Blood Collection Kit and Miscellaneous Collection Kit that are compatible with other tests.

Please note that the Urine Collection Kit is not the actual test, but rather a kit for collecting the urine that will be tested. You will send everything to IGeneX for testing.

$20.00 (This is a non-refundable deposit that will be deducted from your testing fees.)

ADD THIS KIT TO CART

See panel and test list >>

WHAT'S IN THE BOX

Test Requisition Form (click to open)
Instructions
Six Gray Top Tubes
Three Plastic Cups
Three Plastic Transfer Pipettes
Labels
Biohazard Bag
Return Shipping Envelope

TESTS PERFORMED WITH THE URINE COLLECTION KIT

Using a urine sample, IGeneX can perform a broad range of serological and molecular tests for Lyme Disease and Tick-Borne Illnesses:

Lyme Disease Tests
Lyme disease is not only caused by Borrelia burgdorferi, but multiple species of Lyme Borreliae can cause the disease. IGeneX’s Lyme disease tests cover most species.

Tick-Borne Relapsing Fever (TBRF) Tests
TBRF is caused by a different group of species of Borrelia from the group that causes Lyme disease. IGeneX’s TBRF tests include testing for Borrelia miyamotoi disease.

Bartonella Tests
Bartonellosis includes, but is not limited to, Cat Scratch Disease (CSD) and Trench Fever. IGeneX’s multi-species Western Blots include testing for Bartonella henselae, Bartonella quintana, Bartonella elizabethae, and Bartonella vinsonii.

Babesia Tests
Multiple species of Babesia cause babesiosis, and our tests include Babesia microti and Babesia duncani, both of which are found throughout the USA.

Rickettsia Tests
Multiple species of Rickettsia cause rickettsiosis, and one of those species, Rickettsia rickettsia, is known to cause Rocky Mountain Spotted Fever (RMSF). IGeneX tests for Rickettsia rickettsia, Rickettsia typhi, and Rickettsia felis.

Anaplasma Tests
IGeneX tests for Anaplasma phagocytophilum (HGA), one of the causative agents of Anaplasmosis. The same ticks that transmit Lyme disease are known to carry Anaplasma.

Ehrlichia Tests
IGeneX tests for Ehrlichia chaffeesis (HME), one of the causative agents of Ehrlichiosis. The same ticks that transmit Lyme disease are known to carry Ehrlichia.

RESULTS YOU CAN UNDERSTAND

Easy to Understand
Gain meaningful insights about your health with easy-to-understand test results. We also provide you with additional resources and helpful tips along the way.

Detailed Information
Get detailed information on the results of your tests, including information comparing your results based on IGeneX and CDC criteria.

Actionable
Take action on your health and wellness. Use your report to help guide your next steps. Contact your healthcare provider to learn more about your results and get your questions answered.

Easy to Understand
Gain meaningful insights about your health with easy-to-understand test results. We also provide you with additional resources and helpful tips along the way.

Detailed Results
Get detailed information on the results of your tests, including information comparing your results based on IGeneX and CDC criteria.

ADD THIS KIT TO CART

HEAR FROM OUR PATIENTS

"You should get this test... This is the best we have to test for this awful disease."

Hear why one patient thinks IGeneX offers the best tests for Lyme disease and other tick-borne illnesses available in the U.S.

"IGeneX has much more comprehensive testing for Lyme disease."

Timing makes a huge difference when testing for Lyme disease, so it’s important to use the best test for late stage Lyme disease you can find. In this interview, hear about a patient whose undiagnosed Lyme had become chronic and was not showing up on Lyme disease tests. An IGeneX test finally confirmed the infection and set her on her treatment path.

"IGeneX is kind of like the leaders right now in tick-borne disease testing."

Hear one young patient’s excitement about taking an at-home Lyme disease test from IGeneX to determine the cause of her tick-borne disease-like symptoms.

HOW IT WORKS

Order a kit

Order a collection kit right here on the IGeneX website for a small deposit that will be applied to your testing fees.

Complete Paperwork

Complete the paperwork with your doctor to determine which tests IGeneX should conduct with your samples.

Draw Sample

Draw your urine sample in the privacy of your own home.

Get Results

Ship everything to IGeneX. We will conduct the appropriate tests and send the results to your doctor.

IGENEX TESTING REVIEWS

4.94

18 reviews

Bonnie Alexander

May 9, 2022

IB1 Panel Review

My first Lyme test with my primary care doctor did not show a positive, but my symptoms persisted for another six months. I did some herbal therapy which helped ease the aches and nausea, but I still did not feel great and felt I need another test. I chose to get tested at IGeneX after talking with a Lyme literate doctor. The test showed positive for Lyme. It was expensive, but I think worth it ultimately.

see all customer images

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Filter By:

Bernard
February 24, 2023

International testing

My wife has chronic Lyme disease and we live in New Zealand and so can't get testing done in this country because it's not endemic. Over the years we've used Igenex and are very pleased with their communication about the complicated process of an international testing process and with the efficiency of reporting results
d h kendall
February 23, 2023

ease of use

i am unaccustomed to this kind of test, so it was a little confusing to find an office & get it done, but the staff was quite helpful in all regards. i went to the wrong office of the chosen blood-draw lab, but they directed me to a lab closer to my home. i think in a ways, they are concerned with making it as easy as possible for the patient, which i find reassuring. as i said the whole process works like that, so they have the lab send the samples instead of letting m do it, which is good, because they are more likely to do it correctly. all in all, i appreciated the phone advice, the courtesy and knowledge of the customer service personnel, and - again - the ease.
Jacqueline Saa
February 23, 2023

Blood kit

Quest is a joke, so glad Igenex was available so I know exactly what illnesses I have to treat. Easy blood draw and fast results.
Carly
February 15, 2023

Best Lyme testing

Super easy to order, have drawn, and by far the most valuable info received to date about tic borne infection!
Mark K
December 7, 2022

co-infections

After years of being tested by my Lyme doctor and being told all I had was Lyme only to find out I had Bart and a few other co-infections. Because I waited so long it is now attacking my nervous system. Feet and hands have gone numb. All I can do is pray for a cure one day.
Sheila Meyer
June 8, 2022

My initial test was with IGeneX through a physician. So, I wanted the followup test to be an apples-to-apples comparison and it did not disappoint. My only complaint was that, before ordering, I consulted with one of your insurance representatives as I was newly enrolled in Medicare and was assured that the test was covered by the policy I had (which I gave him all of the information he requested). Unfortunately, it turned out that it was not covered .... which delayed the test because I was not receiving the any messages about it. Finally, my "new" doctor's office called me to let me know so that I could contact you, pay for the test upfront so it could be processed. I am happy to say that my tests went from 11 of the 12 positive to no positive. I was thrilled!!
Dr. Myers
June 8, 2022

I came back from a trip to Colorado 4 years ago with an aweful sinus cold and cough in my lungs and it wouldn't go away. I tried everything natural to clear it up and nothing worked. I had all kinds of tests done and my immune system wasn't working but no signs of pnuemonia or cancer in my lungs. Mold tests came back positive but I wasn't currently in an exposure anymore. It wasn't for 2 years until I tested with IGenex and finally found Lyme and Co-infections were the cause of my health issues. I have also used IGenex to test ticks that we have found on our kids and patients. They are the best and most reliable company for testing and diagnosis I have found in my 2 decades of practice!
Kyla P
June 8, 2022

IGeneX is our office's go-to test for Lyme Disease. They give the most comprehensive results and are the easiest test to get our patients to complete. We have almost all our patients tested for Lyme Disease and this is our test of choice!
Megan
June 8, 2022

Though this test was a bit pricey, it was the best decision I've ever made for my health. Taking this test revealed why I had been sick for 3+ years and helped me on the path to recovery. One year later, though still recovering, I'm a much healthier and happier person!
Wendy Spring Gelb
May 23, 2022

Although I've been one of the rare people to get CDC positive results from regular/lower-quality labs like LabCorp. As soon as I was on Medicaid 2 yrs ago I was able to get more extensive testing with igenex which not only confirmed "the 3 B's" (borrelia, bartonella & babesia) it was also the 1st time in 7 yrs that showed positive for TBRF. It was SUCH A BIG BLESSING that igenex accepts Medicare!!! And I was happy to report I was doing well with my treatment from my LLNP based off my results, I had an upsetting recent setback and decided to take another igenex test. This time, we were very surprised to find that I had a DIFFERENT type of Bartonella and DIFFERENT type of Babesia showing positive this round. I doubt other labs would have picked that detail up and it will help with my next treatments. However, what I didn't fully comprehend (probably due to brain fog LOL) was that even though I thought I still was covered by Medicare and the plethora of tests we orderd would be covered again, I got a call from igenex to explain that because I have WellCare as additional insurance, Medicare is no longer my "primary insurance" and therefore my tests were NOT covered. So just be mindful of this when ordering your tests folks! The igenex rep was very kind and explained things with compassion to me. It's expensive but it was worth it for more solid answers that will lead to better treatment. Igenex was also nice enough to ask me if I wanted to proceed with the testing before just going ahead and charging me. One day I hope that enough laws will change to allow all insurance to cover these important tests. Overall, I am a two-time, happily satisfied customer and trust them to use them again if ever needed.

WHY IGENEX FOR TICK-BORNE DISEASE TESTING?

CLIA certified in all 50 states
Long track record of success since 1991
Offers testing that is nearly twice as accurate as CDC recommended tests
Tests for all major tick-borne illnesses, including Lyme disease, TBRF, Babesia, Bartonella, and Rickettsia
Utilizes comprehensive testing methods such as PCR, ImmunoBlots, IgXSpot and FISH
Has become a nationwide leader in COVID-19 testing due to a relentless focus on customer satisfaction

By appointment only. Please send email.

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Home » Stores » A & M Phlebotomy

BLOOD COLLECTION KIT

For most patients, ordering a Blood Collection Kit is the first step in getting tested for Lyme disease or other tick-borne diseases. We also offer a Urine Collection Kit and Miscellaneous Collection Kit, but most tick-borne disease tests offered by IGeneX are compatible with the Blood Collection Kit.

Please note that the Blood Collection Kit is not the actual test, but rather a kit for collecting the blood that will be tested. This is also not an at-home blood collection kit. You need to work with a doctor to order your tests, as well as a blood draw lab to collect your sample. You will then send everything to IGeneX for testing.

$20.00 (This is a non-refundable deposit that will be deducted from your testing fees.)

ADD THIS KIT TO CART

See panel and test list >>

WHAT'S IN THE BOX

Test Requisition Form (click to open)
Instructions
8.5 ML Serum-Separating Tube (Red Top)
6.0 ML Heparin Tube (Green Top)
6.0 ML EDTA Tube (Lavender Top)
Labels
Biohazard Bag
Return Shipping Envelope

TESTS PERFORMED WITH THE BLOOD COLLECTION KIT

Using a blood sample, IGeneX can perform a broad range of serological and molecular tests for Lyme Disease and Tick-Borne Illnesses:

Lyme Disease Tests
Lyme disease is not only caused by Borrelia burgdorferi, but multiple species of Lyme Borreliae can cause the disease. IGeneX’s Lyme disease tests cover most species.

Babesia Tests
Multiple species of Babesia cause babesiosis, and our tests include Babesia microti and Babesia duncani, both of which are found throughout the USA.

Anaplasma Tests
IGeneX tests for Anaplasma phagocytophilum (HGA), one of the causative agents of Anaplasmosis. The same ticks that transmit Lyme disease are known to carry Anaplasma.

Ehrlichia Tests
IGeneX tests for Ehrlichia chaffeesis (HME), one of the causative agents of Ehrlichiosis. The same ticks that transmit Lyme disease are known to carry Ehrlichia.

RESULTS YOU CAN UNDERSTAND

Easy to Understand
Gain meaningful insights about your health with easy-to-understand test results. We also provide you with additional resources and helpful tips along the way.

Detailed Information
Get detailed information on the results of your tests, including information comparing your results based on IGeneX and CDC criteria.

Easy to Understand
Gain meaningful insights about your health with easy-to-understand test results. We also provide you with additional resources and helpful tips along the way.

Detailed Results
Get detailed information on the results of your tests, including information comparing your results based on IGeneX and CDC criteria.

ADD THIS KIT TO CART

HEAR FROM OUR PATIENTS

"I was fortunate about IGeneX."

Mighty Well Brand Officer Emily Levy first contracted Lyme disease at the age of 6, but the infection wasn’t confirmed until she was in college. Hear how a positive result on a Lyme disease test from IGeneX helped finally get her on the path to healing.

"Get the IGeneX test."

Hear one Lyme warrior’s story of using an IGeneX Lyme disease test to confirm the source of her illness.

"IGeneX tests all of them."

Like many Lyme patients, Holly Owens had her symptoms misdiagnosed for years before discovering the real source of her symptoms. Then a Lyme-literate doctor helped her get tested with IGeneX to finally confirm her infections of Lyme disease and Babesiosis.

HOW IT WORKS

Order a kit

Order a collection kit right here on the IGeneX website for a small deposit that will be applied to your testing fees.

Complete Paperwork

Complete the paperwork with your doctor to determine which tests IGeneX should conduct with your samples.

Get Blood Drawn

Take your collection kit to a blood draw site to have your sample collected.

Get Results

Ship everything to IGeneX. We will conduct the appropriate tests and send the results to your doctor in 7-10 business days..

IGENEX TESTING REVIEWS

4.94

18 reviews

Bonnie Alexander

May 9, 2022

IB1 Panel Review

see all customer images

Sort By:

Filter By:

Bernard
February 24, 2023

International testing

My wife has chronic Lyme disease and we live in New Zealand and so can't get testing done in this country because it's not endemic. Over the years we've used Igenex and are very pleased with their communication about the complicated process of an international testing process and with the efficiency of reporting results
d h kendall
February 23, 2023

ease of use

i am unaccustomed to this kind of test, so it was a little confusing to find an office & get it done, but the staff was quite helpful in all regards. i went to the wrong office of the chosen blood-draw lab, but they directed me to a lab closer to my home. i think in a ways, they are concerned with making it as easy as possible for the patient, which i find reassuring. as i said the whole process works like that, so they have the lab send the samples instead of letting m do it, which is good, because they are more likely to do it correctly. all in all, i appreciated the phone advice, the courtesy and knowledge of the customer service personnel, and - again - the ease.
Jacqueline Saa
February 23, 2023

Blood kit

Quest is a joke, so glad Igenex was available so I know exactly what illnesses I have to treat. Easy blood draw and fast results.
Carly
February 15, 2023

Best Lyme testing

Super easy to order, have drawn, and by far the most valuable info received to date about tic borne infection!
Mark K
December 7, 2022

co-infections

After years of being tested by my Lyme doctor and being told all I had was Lyme only to find out I had Bart and a few other co-infections. Because I waited so long it is now attacking my nervous system. Feet and hands have gone numb. All I can do is pray for a cure one day.
Sheila Meyer
June 8, 2022

My initial test was with IGeneX through a physician. So, I wanted the followup test to be an apples-to-apples comparison and it did not disappoint. My only complaint was that, before ordering, I consulted with one of your insurance representatives as I was newly enrolled in Medicare and was assured that the test was covered by the policy I had (which I gave him all of the information he requested). Unfortunately, it turned out that it was not covered .... which delayed the test because I was not receiving the any messages about it. Finally, my "new" doctor's office called me to let me know so that I could contact you, pay for the test upfront so it could be processed. I am happy to say that my tests went from 11 of the 12 positive to no positive. I was thrilled!!
Dr. Myers
June 8, 2022

I came back from a trip to Colorado 4 years ago with an aweful sinus cold and cough in my lungs and it wouldn't go away. I tried everything natural to clear it up and nothing worked. I had all kinds of tests done and my immune system wasn't working but no signs of pnuemonia or cancer in my lungs. Mold tests came back positive but I wasn't currently in an exposure anymore. It wasn't for 2 years until I tested with IGenex and finally found Lyme and Co-infections were the cause of my health issues. I have also used IGenex to test ticks that we have found on our kids and patients. They are the best and most reliable company for testing and diagnosis I have found in my 2 decades of practice!
Kyla P
June 8, 2022

IGeneX is our office's go-to test for Lyme Disease. They give the most comprehensive results and are the easiest test to get our patients to complete. We have almost all our patients tested for Lyme Disease and this is our test of choice!
Megan
June 8, 2022

Though this test was a bit pricey, it was the best decision I've ever made for my health. Taking this test revealed why I had been sick for 3+ years and helped me on the path to recovery. One year later, though still recovering, I'm a much healthier and happier person!
Wendy Spring Gelb
May 23, 2022

Although I've been one of the rare people to get CDC positive results from regular/lower-quality labs like LabCorp. As soon as I was on Medicaid 2 yrs ago I was able to get more extensive testing with igenex which not only confirmed "the 3 B's" (borrelia, bartonella & babesia) it was also the 1st time in 7 yrs that showed positive for TBRF. It was SUCH A BIG BLESSING that igenex accepts Medicare!!! And I was happy to report I was doing well with my treatment from my LLNP based off my results, I had an upsetting recent setback and decided to take another igenex test. This time, we were very surprised to find that I had a DIFFERENT type of Bartonella and DIFFERENT type of Babesia showing positive this round. I doubt other labs would have picked that detail up and it will help with my next treatments. However, what I didn't fully comprehend (probably due to brain fog LOL) was that even though I thought I still was covered by Medicare and the plethora of tests we orderd would be covered again, I got a call from igenex to explain that because I have WellCare as additional insurance, Medicare is no longer my "primary insurance" and therefore my tests were NOT covered. So just be mindful of this when ordering your tests folks! The igenex rep was very kind and explained things with compassion to me. It's expensive but it was worth it for more solid answers that will lead to better treatment. Igenex was also nice enough to ask me if I wanted to proceed with the testing before just going ahead and charging me. One day I hope that enough laws will change to allow all insurance to cover these important tests. Overall, I am a two-time, happily satisfied customer and trust them to use them again if ever needed.

WHY IGENEX FOR TICK-BORNE DISEASE TESTING?

CLIA certified in all 50 states
Long track record of success since 1991
Offers testing that is nearly twice as accurate as CDC recommended tests
Tests for all major tick-borne illnesses, including Lyme disease, TBRF, Babesia, Bartonella, and Rickettsia
Utilizes comprehensive testing methods such as PCR, ImmunoBlots, IgXSpot and FISH
Has become a nationwide leader in COVID-19 testing due to a relentless focus on customer satisfaction

GET STARTED WITH IGENEX TODAY

The first step in getting tested with IGeneX is to order a test collection kit. Choose between a Blood, Urine, or Miscellaneous kit, depending on the test you will be doing. The Blood Kit is the most common, and works with 95% of tests. Doctors can order unlimited quantities of kits at no charge. Patients are required to deposit $20, which is applied to the testing fees.

Learn more

Resources

Download forms, policies, pricing, and other helpful information for ordering testing services from IGeneX.

If you have any questions, please contact us directly at
1-800-832-3200, or send a message to customerservice@igenex.com.

Home » Stores » A & M Phlebotomy

FORMS & POLICIES

Domestic

International

Prices & Billing

Medicare

COVID-19

INSTRUCTIONAL VIDEO

Need help with the Test Requisition Form?

Watch the interactive video below for step-by-step instructions on how to fill out the form and select the appropriate tests or test panels.

Click on the menu in the top left of the video to jump to a specific section of the TRF.

Checkout

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Blood Draw Sites

Covers RI, CT, and MA.

Diagnostic Tests for Lyme Disease

Lyme disease (Lyme borreliosis) is the most common vector-borne disease in the United States according to the CDC.

Home » Stores » A & M Phlebotomy

ABOUT GENUS BORRELIA - LYME DISEASE

Borreliosis is a worldwide infectious disease caused by spiral-shaped bacteria known as Borreliae, carried by ticks and louse. Although about 20 classifications of Borrelia exist, the species of Borreliae known to cause disease in humans are split into the following two groups:

B. burgdorferi sensu lato, which causes Lyme disease
Relapsing Fever Borrelia, which causes Tick-Borne Relapsing Fever (TBRF)

It’s important to note that each of these broad groups includes several Borrelia sub-species and strains, and researchers continue to discover more. It is not uncommon for patients to receive false negatives simply because the test they took was not designed to detect the species of Borrelia causing their infection.

THE IMPORTANCE OF DIAGNOSTIC TESTS FOR BORRELIA

Called the “great imitator,” Lyme disease can present a variety of symptoms that mimic a wide range of illnesses, including chronic fatigue syndrome, fibromyalgia, ALS, Alzheimer’s disease, depression, insomnia, and autoimmune disorders such as RA and Multiple Sclerosis (MS). In addition, many tick-borne infections go misdiagnosed for months because these nonspecific symptoms mirror other illnesses. Thus, laboratory testing is frequently required to confirm a diagnosis.

CDC-RECOMMENDED TWO-TIERED BORRELIA TESTING

Lyme disease is typically diagnosed by a two-tiered testing (TTT) approach involving an enzyme-linked immunosorbent assay (ELISA) followed by a Western blot test. However, the sensitivity of these commercially available tests is poor, meaning they can miss active infections. Experts advise against this testing technique due to the ambiguity of its results.

IGeneX has developed several Borrelia burgdorferi tests that provide higher sensitivity to detect and speciate the B. burgdorferi group. When used in conjunction with clinical symptoms and patient history, the tests listed below can better assist physicians in accurately diagnosing patients. Keep reading to learn more about Lyme borreliosis, including symptoms, prevalence, and, if necessary, which IGeneX test to order.

WHAT TESTS ARE AVAILABLE FOR LYME DISEASE?

IGeneX offers ImmunoBlots, Serologies, Western Blots, PCRs (Polymerase Chain Reaction), Culture Enhanced PCR (cePCR), IgXSpot, Broad Coverage Assays, and LSA tests to confirm the diagnosis of Lyme Disease.

Lyme IgG/IgM Antibody Serology

The IgG/IgM Antibody Serology test is an ELISA (enzyme linked immunoassay), which indicates the presence of both IgG and IgM antibodies to B. burgdorferi. IgM antibodies are present shortly after infection takes place. IgG antibodies often persist long after symptoms have disappeared. The presence of either IgG/IgM antibodies indicates exposure to Lyme-causing Borrelia, not the active disease. A positive or equivocal test must be confirmed by both IgG and IgM ImmunoBlots Blots.

Reference Range
Borrelia burgdoferi Antibody Serology IgG/IgM

Negative <1.0

Equivocal 1.0 to <1.2

Positive 1.2

Clinical Significance
This test is recommended at least four weeks after exposure. Patients diagnosed with Lyme disease based on clinical history have positive IgG/IgM serology results within one year of the tick bite, approximately 70% of the time. The percentage of patients with a positive serology is reduced in subsequent years.

All samples with positive or equivocal results should be tested with B. burgdorferi Western Blots.

Limitations

This test should only be performed in conjunction with Western Blots/ ImmunoBlots.
Cross Reacting Antibodies:
- Sera from patients with other pathogenic spirochetal diseases such as syphilis, yaws, pinta, leptospirosis, and relapsing fever may give false-positive results.
- Sera from patients with mononucleosis or lupus erythomatosis (LE) may also give false-positive results.
- In cases where false-positive results occur, clinical epidemiological and laboratory workups should be carried out. Active syphilis and Lyme disease can be differentiated by the use of VDRL or RPR tests. In active syphilis, the VDRL and RPR are positive, whereas in Lyme disease they are not.
Antibiotic therapy given early in the disease may prevent the development of an antibody response. Negative results early in the disease have a low predictive value. Retesting may be warranted if symptoms consistent with Lyme disease persist.
The evaluation must include a review of all test results, the clinical history presented by the patient, the patient’s exposure to endemic regions for Lyme disease, epidemiological data, and potential exposure to other spirochetal diseases.
The use of this assay has not been evaluated for individuals who have received a Lyme disease vaccine.

Stage of Disease
Screen test

Results Interpretation >
View Lyme disease serology tests >

Lyme IgM Antibody Serology

The IgG/IgM Antibody Serology test is an ELISA (enzyme linked immunoassay) format, and it detects the presence of IgM antibodies to B. burgdorferi after exposure to an infected tick. Because IgM antibodies appear early in response to infection, this test may be positive two to six weeks after exposure. But since the level of IgM rapidly declines over time, testing for IgM antibodies too late can cause a missed infection.

A positive or equivocal IgM antibody test must be confirmed by an IgM Western Blot or Lyme ImmunoBlot IgM. NOTE: The sensitivity concerns mentioned for the IgG/IgM assay also affect this assay.

Reference Range
Borrelia burgdorferi Antibody Serology IgM

Negative <0.8

Equivocal 0.8 to <1.2

Positive 1.2

Clinical Significance
The Lyme IgM antibody ELISA is a serological test for the detection of IgM antibodies to B. burgdorferi after possible exposure to an infected tick. IgM antibodies appear early in response to infection; therefore, this test may be positive between 2 to 6 weeks after exposure. Though the level of IgM declines over time, the IgM response may persist in patients with prolonged illness, and a new IgM response may appear later in persistent or recurrent disease or from re-infection. Therefore, this test is recommended approximately 2 weeks after suspected exposure to Lyme.

All samples with positive or equivocal results should be tested with B. burgdorferi Western Blots or Lyme ImmunoBlots.

Limitations

This test should only be performed in conjunction with Western Blots/ ImmunoBlots.
Cross Reacting Antibodies:
- Sera from patients with other pathogenic spirochetal diseases such as syphilis, yaws, pinta, leptospirosis, and relapsing fever may give false positive results.
- Sera from patients with mononucleosis or lupus erythomatosis (LE) may also give false positive results.
- In cases where false positive results occur, clinical epidemiological and laboratory workups should be carried out. Active syphilis and Lyme disease can be differentiated by the use of VDRL or RPR tests. In active syphilis, the VDRL and RPR are positive, and in Lyme disease they are not.
Antibiotic therapy given early in the disease may prevent the development of an antibody response. Negative results early in the disease have a low predictive value. Retesting may be warranted if symptoms consistent with Lyme disease persist.
The evaluation must include all test results, the clinical history presented by the patient, the patient’s exposure to endemic regions for Lyme disease, epidemiological data, and any potential exposure to other spirochetal diseases.
Positive or equivocal first-tier test results should not be reported until second-tier testing of the specimen is performed using a method that is more specific, such as Western Blot/ ImmunoBlot.
The use of this assay has not been evaluated for individuals who have received a Lyme disease vaccine.

Stage of Disease
Screen test

Results Interpretation >
View Lyme disease serology tests >

Lyme Screen Immunoassay (LSA) - NEW!

Note: The LSA replaces the Lyme IFA and should be used as a screening test in conjunction with the Lyme ImmunoBlots. The sensitivity and specificity of the LSA is superior to the IFA, but is not meant to be a standalone test. The LSA has also replaced the IFA in test panels.

The Lyme Screen Immunoassay is a qualitative test designed to detect IgM or IgG antibodies to Lyme Borreliae group-specific antigens in human serum. The combined sensitivity of the Lyme Screen Immunoassay is 85%, and the combined specificity is 94%.

Principle
The test detects IgM or IgG antibodies to the Lyme Borreliae group, and should be used in conjunction with ImmunoBlots, as well as patient clinical symptoms and history.

Results
Positive: Lyme Borreliae antigens detected
Negative: Lyme Borreliae antigens not detected

Clinical Significance
A positive test suggests exposure to the Lyme Borreliae group and should be used in conjunction with ImmunoBlots, as well as the patient’s clinical symptoms and history.

Limitations

This test should be used only for screening purposes.
A negative LSA does not exclude the possibility of infection with B. burgdorferi.
IGeneX interpretation is based on internal validation studies.
The results of this test must be interpreted in relation to patient’s clinical history, epidemiological data, stage of disease, clinical symptoms or other laboratory results.

Special Instructions
This test is not yet available for NY residents.

Stage of Disease
Screen test

View LSA tests >

Lyme Broad Coverage Ab Assay

Principle
The Lyme Broad Coverage Antibody (BCA) Assay is a qualitative test designed to detect IgM/IgG antibodies to Lyme Borreliae group-specific antigens in human serum.

Clinical Significance
A positive test suggests exposure to the Lyme Borreliae group and should be used in conjunction with the patient’s clinical symptoms and history. The BCA Assay is a simple and cost-effective test that gives straightforward positive or negative results.

Performance Characteristics
The sensitivity of the Lyme BCA Assay is 90%, and the specificity is 97%.

Limitations

For specific protein or band information, an ImmunoBlot IgM or IgG test should be ordered to provide more information and possible speciation of the Borrelia.
A negative Lyme ImmunoBlot IgG does not exclude the possibility of infection with B. burgdorferi.
IGeneX interpretation is based on internal validation studies.
The results of this test must be interpreted in relation to patient’s clinical history, epidemiological data, stage of disease, clinical symptoms or other laboratory results.

Stage of Disease
Early disease / Re-activation later

Results Interpretation >
View BCA tests >

Lyme ImmunoBlot

The Lyme ImmunoBlot is a qualitative immunoassay in which antibodies specific to the B. burgdorferi antigens on a membrane strip are visualized. It is a qualitative test and is more sensitive and specific than the ELISA, IFA, and traditional Western Blot tests for lyme. When antibody levels are very low in the early or late stage of the disease, ImmunoBlot can be positive, whereas ELISA and IFA tests can be negative.

This test must be used if the Lyme IgG/IgM antibody or Lyme IgG/IgA/IgM IFA is positive or equivocal.

Principle

The Lyme ImmunoBlot assay is based upon an antigen-antibody complex formation in the following steps:

Binding of anti-Borrelia-specific antibodies in human serum to the ImmunoBlot strip. The ImmunoBlot strip is a membrane strip with fixed B. burgdorferi recombinant antigens on it.
Binding of enzyme labeled anti-human IgG or IgM antibodies to the human anti Borrelia antibodies bound to fixed B. burgdorferi antigens on the membrane.
Reaction with BCIP/NBT, a chromogenic substrate with bound antibodies on the strip. A dark purple colored precipitate (band) develops on the antigen-antibody complexes.

Stage of Disease
Early disease / Re-activation later

Results Interpretation >
View Lyme disease ImmunoBlot tests >

Lyme ImmunoBlot IgM
The Lyme ImmunoBlot IgM is a very sensitive indicator of exposure to B. burgdorferi. It may be positive as early as two weeks after a tick bite and will usually remain positive for six to eight weeks after initial exposure; in some patients, it can remain positive for even longer. Re-exposure will also cause this test to be positive for a brief period of time.

For the Lyme ImmunoBlot testing to be complete, the IgM ImmunoBlot should be run along with the IgG ImmunoBlot.

Reference Range
Negative <2 starred bands present on the blot

Clinical Significance
This test is recommended to be performed at least two weeks after possible exposure. The Lyme ImmunoBlot test must be performed on any sample with positive or equivocal results for Lyme IgG/IgM antibody serology or Lyme IgG/IgA/IgM IFA. It should, ideally, be run alongside the IgG ImmunoBlot.

Limitations

Patients with other spirochetal disease and/or who test positive for rheumatoid factor or Epstein Barr virus may have cross-reacting antibodies and may have positive results for 31, 41, and/or 83 kDa antigens.
Positive results for 31 kDa antigens may be present after Lyme vaccination in uninfected persons.
A negative ImmunoBlot does not exclude the possibility of infection with B. burgdorferi.
IGeneX interpretation is based on internal validation studies.
The results of this test must be interpreted in relation to the patient’s clinical history, epidemiological data, stages of the disease, clinical symptoms, or other laboratory results.

The presence of bands 23-25, 31, 34, 39 or 83-93kDa as indeterminate or presence of only one of these bands in a negative report may indicate clinical significance. Therefore, we recommend testing with another method and/or retesting in 4-6 weeks.

Stage of Disease
Early disease / Re-activation later

Results Interpretation >
View Lyme disease ImmunoBlot tests >

Lyme ImmunoBlot IgG
The IgG ImmunoBlot is an immunoassay and qualitative test in which antibodies are visualized. The IgG antibody is typically present a few months following initial infection.

Reference Range
Negative <2 starred bands present on the blot

Clinical Significance
The Lyme ImmunoBlot IgG is a sensitive indicator of an exposure to B. burgdorferi. IgG antibody is typically present a few months following the initial infection. Lyme ImmunoBlot IgG/IgM must be performed on any sample with positive or equivocal results for Lyme IgG/IgM antibody serology or Lyme IgG/IgA/IgM IFA.

Limitations

Positive results for 31 and/or 34 kDa may be present after Lyme vaccination in uninfected persons.
A negative Lyme ImmunoBlot IgG does not exclude the possibility of infection with B. burgdorferi.
IGeneX interpretation is based on internal validation studies.
The results of this test must be interpreted in relation to patient’s clinical history, epidemiological data, stage of disease, clinical symptoms or other laboratory results.

The presence of an indeterminate number of double-starred bands in a negative report may indicate clinical significance. Therefore, we recommend testing with another method and/or retesting in 4-6 weeks.

Stage of Disease
Later disease

Results Interpretation >
View Lyme disease ImmunoBlot tests >

Lyme Western Blot

The Lyme Western Blot is a qualitative immunoassay in which antibodies specific to the B. burgdorferi antigens on a membrane strip are visualized. It is a qualitative test and is generally more sensitive and specific than the ELISA and IFA tests. When antibody levels are very low in the early or late stage of the disease, the Western Blot can be positive, whereas ELISA and IFA tests can be negative. If the Lyme IgG/IgM antibody serology or Lyme IgG/IgA/IgM IFA is positive or equivocal, this test must be used.

Principle

The Lyme Western Blot assay is based upon an antigen-antibody complex formation in the following steps:

Binding of anti-Borrelia specific antibodies in human serum to the Western Blot strip. The Western Blot strip is a membrane strip with fixed B. burgdorferi antigens separated by size.
Binding of enzyme labeled anti-human IgG or IgM antibodies to the human anti-Borrelia antibodies bound to fixed B. burgdorferi antigens on the membrane.
Reaction with BCIP/NBT, a chromogenic substrate with bound antibodies on the strip. A dark purple colored precipitate (band) develops on the antigen-antibody complexes.

Stage of Disease
Early disease / Re-activation later

Results Interpretation >
View Lyme disease Western blot tests >

Lyme Western Blot IgM
The Lyme Western Blot IgM is a very sensitive indicator of exposure to B. burgdorferi. It may be positive as early as 1 week after a tick bite, will usually remain positive for six to eight weeks after initial exposure, and in some patients will remain positive for much longer. Re-exposure will also cause this test to be positive for a brief period of time. For the testing to be complete, it is preferable that the IgM Western Blot be run along with the IgG Western Blot.

Reference Range
Negative: <2 double starred bands present on the blot

Limitations

Patients with other spirochetal diseases and/or who test positive for rheumatoid factor or Epstein Barr virus may have cross-reacting antibodies and may have a positive result for 31, 41, and/or 83 kDa antigens
Positive results for 31 and/or 34 kDa antigens may be present after Lyme vaccination in uninfected persons.
A negative Western Blot does not exclude the possibility of infection with B. burgdorferi.
IGeneX interpretation is based on internal validation studies.
The results of this test must be interpreted in relation to patient’s clinical history, epidemiological data, stages of disease, clinical symptoms or other laboratory results.

Presence of bands 23-25, 31, 34, 39 and 83-93 kDa as indeterminate, or presence of only one of these bands in a negative report, may indicate clinical significance. Therefore, we recommend testing with another method and/or retesting in 4-6 weeks.

Stage of Disease
Early disease / Re-activation later

Results Interpretation >
View Panel & Test Price List >
View Lyme disease Western blot tests >

Lyme Western Blot IgG
The IgG Western Blot is an immunoassay and qualitative test in which antibodies are visualized. The IgG antibody is typically present a few months following initial infection.

Clinical Significance
The Lyme Western Blot IgG is a sensitive indicator of exposure to B. burgdorferi. IgG antibody is typically present a few months following the initial infection. Lyme Western Blot IgG must be performed on any sample with a positive or equivocal result for Lyme IgG/IgM antibody serology or Lyme IgG/IgA/IgM IFA.

Limitations

Patients with other spirochetal disease and/or who test positive for rheumatoid factor or Epstein Barr virus may have cross-reacting antibodies and may have a positive result for proteins 31, 41.
Positive results for 31 and/or 34 kDa may be present after Lyme vaccination in uninfected persons.
A negative Lyme Western Blot IgG does not exclude the possibility of infection with B. burgdorferi.
IGeneX interpretation is based on internal validation studies.
The results of this test must be interpreted in relation to patient’s clinical history, epidemiological data, stages of disease, clinical symptoms or other laboratory results.

Presence of an indeterminate number of double starred bands in a negative report may indicate clinical significance. Therefore, we recommend testing with another method and/or retesting in 4-6 weeks.

Stage of Disease
Later disease

Results Interpretation >
View Panel & Test Price List >
View Lyme disease Western blot tests >

Lyme IgM and IgG 31kDa Epitope Test

The Lyme IgG or IgM 31kDa Epitope test is a qualitative immunoblot assay that determines whether the 31kDa band present on a Lyme Western Blot IgG or IgM is due to B. burgdorferi specific antibodies.

Reference Range
Negative – No visible bands present

Clinical Significance
It is known that Western blot tests, especially IgM, can give false positive results with some viral and bacterial infections. This test determines whether the band present at position 31 kDa on the IGeneX Lyme Western Blot IgM is specific for B. burgdorferi. Serum from the patient is tested against a Western Blot strip with fixed Borrelia burgdorferi-specific recombinant antigen fragments.

Limitations

This test is only performed on samples previously tested by Lyme Western Blot IgM at IGeneX and have a band at 31kDa position on the blot.
Positive results for the 31kDa band may be present after vaccination in uninfected persons.
IGeneX interpretation is based on internal validation studies.
The results of this test must be interpreted in relation to patient’s clinical history, epidemiological data, stages of disease, clinical symptoms or other laboratory results.

Special Instructions
This test is not yet available for NY residents.

Stage of Disease
Screen test

Results Interpretation >
View Lyme disease Epitope tests >

Lyme Multiplex PCR

The Lyme Multiplex PCR-based diagnostic test for Borrelia burgdorferi is performed directly on a clinical specimen. The combination of the following three steps imparts very high specificity and sensitivity:

Hybridization/Selection
Amplification of the specific DNA (genomic and plasmid)
Detection of B. burgdorferi-specific amplified DNA fragments by dot-blot assay using B. burgdorferi-specific probes.

Reference Range
Negative- Genomic: B. burgdorferi DNA not detected

Negative- Plasmid: B. burgdorferi DNA not detected

Clinical Significance
The Lyme Multiplex PCR test is a 3-step amplified nucleic acid assay that detects B. burgdorferi-specific DNA sequences. The gene fragments are first selected with specific probes. Then, DNA is amplified in two independent PCR assays using different primers from the Osp A gene and flagellin gene. Lastly, the amplified products are detected by hybridizations to specific probes in a Southern Dot-Blot Assay. This test detects DNA from B. burgdorferi, B. afzelii, B. andersonii, B. garinii, and B. mayoni (based on sequence information). The sample is considered positive if either the genomic or plasmid result is positive.

Limitations

Results should be interpreted in conjunction with other laboratory and clinical findings.
Test results can only help the physician in confirming clinical diagnosis.

Stage of Disease
Any stage of disease (Early to late / Chronic stage)

Results Interpretation >
View Lyme disease PCR tests >

Lyme Dot-blot Assay (LDA)

The Lyme Dot-blot Assay (LDA) is a qualitative immunoassay for detecting Borrelia specific antigens in urine using anti-B. burgdorferi antibodies.

Reference Range
Negative: No B. burgdorferi antigens detected

Limitations

Negative tests do not exclude diagnosis of Lyme disease
Cross-reactions with Leptospira may occur.
False positive may occur for patients with a Urinary Tract Infection (UTI), currently being treated for a UTI, or who have undergone treatment for a UTI within the last two weeks.
Test results should be interpreted in conjunction with other laboratory and clinical findings.

Special Instructions
This test is not yet available for NY residents. Test 805 is included in panel 875.

Stage of Disease
Any stage of disease (Early to late / Chronic stage)

Results Interpretation >
View Lyme disease LDA tests >

Lyme IgXSpot

The Lyme IgXSpot is an Enzyme-Linked ImmunoSpot assay that detects human T cells reactive to B. burgdorferi-specific antigens in vitro. It is well documented that both humoral and cellular immune responses develop in Borrelia infection. The cellular immune response develops much earlier than the humoral response in most patients infected with B. burgdorferi. In some patients, sero-conversion from cellular to humoral response does not occur or occurs much later in disease; and in some patients with chronic form of the disease, the humoral response is poor. Thus, the Lyme IgXSpot test is recommended for detection of very early and/or late B. burgdorferi infection and in seronegative patients’ whole blood samples.

Download Lyme IgXSpot Data Sheet >

Principle
IgXSpot is an Enzyme-Linked ImmunoSpot (ELISPOT) assay that detects human T-cells reactive to B. burgdorferi-specific antigens in vitro. ELISPOT is a widely used method for detecting and monitoring cellular immune responses to specific antigens. The IgXSpot assay allows visualization of the secretory product(s) of individual activated or responding cells to B. burgdorferi-specific antigens. Each spot that develops in the assay represents a single reactive cell.

Advantage
The IgXSpot detects specific T-cell responses soon after infection, when antibodies to the organisms are not detectable, or late in the disease when the levels of antibodies are minimal. When combined with Lyme ImmunoBlot tests, IgXSpot provides information on the full spectrum of a patient’s immune response to infection and stage of the disease. It is, therefore, especially useful for seronegative patients.

Reference Range
>2 colonies positive.

Clinical Significance
Assessment of the function and frequency of Borrelia-specific T cells is crucial for evaluating the cellular immune response to and diagnosis of Borrelia infection. Due to the clonal expansion (proliferation) of antigen-specific T cells in vivo during an immune response— increased frequencies of Borrelia antigen-specific effector/memory T cells in peripheral blood suggest prior infection/exposure. In addition, because of the apparent prevalence of either humoral or cellular immunity in infected individuals, the combination of the B. burgdorferi IgXSpot with Lyme serology assay would further increase the sensitivity of Lyme disease diagnosis.

Limitations
For diagnostic purposes, the IgXSpot test results should be used in conjunction with clinical symptoms and other evidence available to the diagnosing physician.

Stage of Disease
Early disease / Later re-activation

Results Interpretation >
View Lyme disease IgXSpot tests >

Lyme cePCR - New!

Culture testing is widely considered to be the “gold standard” for diagnosis of Lyme disease. For many years, Lyme disease cultures were too expensive and tedious to be practical for laboratory use. Until now. After many years of research and development, IGeneX is pleased to introduce cePCR (Culture-Enhanced PCR) for Lyme disease.

Download the cePCR datasheet >

Principle
In culturing, a clinical sample from the body (e.g. blood) is incubated in media.
During this incubation period, micro-organisms in the sample grow and multiply. The sample is then tested by PCR to identify the pathogens.

Advantages of Culture-Enhanced PCR
• Provides higher sensitivity than standard PCR testing.
• The only 100% specific method for identification of Lyme disease.
• Obtaining cultures before antibiotic use improves the chances of identifying the offending microorganism, which improves patient care.

Stage of Disease
Any stage

View Lyme disease cePCR tests >

Complete Test Directory

Find in-depth information on IGeneX’s tests for Lyme disease, Tick-Borne Relapsing Fever, Bartonellosis, Babesiosis, Rickettsiosis, Anaplasmosis, Ehrlichiosis, and COVID-19.

Quickly filter by price, disease, methodology, New York availability, specimen type, and more.

THE DIRECTORY

GET STARTED TODAY!

The first step in getting tested with IGeneX is to order a collection kit. Choose between a Blood, Urine, or Miscellaneous kit. Doctors can order unlimited quantities of kits at no charge. Patients are required to deposit $20, which is applied to the testing fees.

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MISC. COLLECTION KIT

The Miscellaneous Collection Kit is compatible with Lyme disease and tick-borne illness tests that require samples other than blood or urine, such as cerebral spinal fluid (CSF), tissue, placenta, breast milk, etc. We also offer a Blood Collection Kit and Urine Collection Kit that are compatible with other tests.

Please note that the Urine Collection Kit is not the actual test, but rather a kit for collecting the urine that will be tested. You will send everything to IGeneX for testing.

$20.00 (This is a non-refundable deposit that will be deducted from your testing fees.)

ADD THIS KIT TO CART

See panel and test list >>

WHAT'S IN THE BOX

Test Requisition Form (click to open)
Instructions
8.5 ML Serum-Separating Tube (Red Top)
6.0 ML EDTA Tube (Lavender Top)
Clear Tube (White Top)
Ice Pack
Labels
Biohazard Bag
Return Shipping Envelope

TESTS PERFORMED WITH THE MISC. COLLECTION KIT

Using a miscellaneous sample, IGeneX can perform a broad range of serological and molecular tests for Lyme Disease and Tick-Borne Illnesses:

Lyme Disease Tests
Lyme disease is not only caused by Borrelia burgdorferi, but multiple species of Lyme Borreliae can cause the disease. IGeneX’s Lyme disease tests cover most species.

RESULTS YOU CAN UNDERSTAND

Easy to Understand
Gain meaningful insights about your health with easy-to-understand test results. We also provide you with additional resources and helpful tips along the way.

Detailed Information
Get detailed information on the results of your tests, including information comparing your results based on IGeneX and CDC criteria.

Easy to Understand
Gain meaningful insights about your health with easy-to-understand test results. We also provide you with additional resources and helpful tips along the way.

Detailed Results
Get detailed information on the results of your tests, including information comparing your results based on IGeneX and CDC criteria.

ADD THIS KIT TO CART

HEAR FROM OUR PATIENTS

"So you had the IGeneX test, which is far better than the traditional testing."

One patient couldn’t get the answers she needed about her symptoms even from an infectious disease specialist. The accuracy and sensitivity of IGeneX tests helped her get the diagnosis she needed to start treatment and get her life back.

"The IGeneX test is the gold standard in Lyme because they catch everything."

Hear podcaster and Empowerment Coach Liza Blas tell the story of confirming Lyme disease infections in both of her kids through an IGeneX test.

"You need to get an IGeneX test. It's not cheap, but you need to get this done."

Craig and Maria Emmerich talk about Craig’s long journey to finally getting positive results on a Lyme disease test. Hear how IGeneX helped confirm the chronic Lyme he had been struggling with for at least 6 years, leading to chronic pain, weight loss, and more.

HOW IT WORKS

Order a kit

Order a collection kit right here on the IGeneX website for a small deposit that will be applied to your testing fees.

Complete Paperwork

Complete the paperwork with your doctor to determine which tests IGeneX should conduct with your samples.

Get Sample Drawn

Take your collection kit to a specialist to get your sample drawn.

Get Results

Ship everything to IGeneX. We will conduct the appropriate tests and send the results to your doctor.

IGENEX TESTING REVIEWS

4.94

18 reviews

Bonnie Alexander

May 9, 2022

IB1 Panel Review

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Bernard
February 24, 2023

International testing

My wife has chronic Lyme disease and we live in New Zealand and so can't get testing done in this country because it's not endemic. Over the years we've used Igenex and are very pleased with their communication about the complicated process of an international testing process and with the efficiency of reporting results
d h kendall
February 23, 2023

ease of use

i am unaccustomed to this kind of test, so it was a little confusing to find an office & get it done, but the staff was quite helpful in all regards. i went to the wrong office of the chosen blood-draw lab, but they directed me to a lab closer to my home. i think in a ways, they are concerned with making it as easy as possible for the patient, which i find reassuring. as i said the whole process works like that, so they have the lab send the samples instead of letting m do it, which is good, because they are more likely to do it correctly. all in all, i appreciated the phone advice, the courtesy and knowledge of the customer service personnel, and - again - the ease.
Jacqueline Saa
February 23, 2023

Blood kit

Quest is a joke, so glad Igenex was available so I know exactly what illnesses I have to treat. Easy blood draw and fast results.
Carly
February 15, 2023

Best Lyme testing

Super easy to order, have drawn, and by far the most valuable info received to date about tic borne infection!
Mark K
December 7, 2022

co-infections

After years of being tested by my Lyme doctor and being told all I had was Lyme only to find out I had Bart and a few other co-infections. Because I waited so long it is now attacking my nervous system. Feet and hands have gone numb. All I can do is pray for a cure one day.
Sheila Meyer
June 8, 2022

My initial test was with IGeneX through a physician. So, I wanted the followup test to be an apples-to-apples comparison and it did not disappoint. My only complaint was that, before ordering, I consulted with one of your insurance representatives as I was newly enrolled in Medicare and was assured that the test was covered by the policy I had (which I gave him all of the information he requested). Unfortunately, it turned out that it was not covered .... which delayed the test because I was not receiving the any messages about it. Finally, my "new" doctor's office called me to let me know so that I could contact you, pay for the test upfront so it could be processed. I am happy to say that my tests went from 11 of the 12 positive to no positive. I was thrilled!!
Dr. Myers
June 8, 2022

I came back from a trip to Colorado 4 years ago with an aweful sinus cold and cough in my lungs and it wouldn't go away. I tried everything natural to clear it up and nothing worked. I had all kinds of tests done and my immune system wasn't working but no signs of pnuemonia or cancer in my lungs. Mold tests came back positive but I wasn't currently in an exposure anymore. It wasn't for 2 years until I tested with IGenex and finally found Lyme and Co-infections were the cause of my health issues. I have also used IGenex to test ticks that we have found on our kids and patients. They are the best and most reliable company for testing and diagnosis I have found in my 2 decades of practice!
Kyla P
June 8, 2022

IGeneX is our office's go-to test for Lyme Disease. They give the most comprehensive results and are the easiest test to get our patients to complete. We have almost all our patients tested for Lyme Disease and this is our test of choice!
Megan
June 8, 2022

Though this test was a bit pricey, it was the best decision I've ever made for my health. Taking this test revealed why I had been sick for 3+ years and helped me on the path to recovery. One year later, though still recovering, I'm a much healthier and happier person!
Wendy Spring Gelb
May 23, 2022

Although I've been one of the rare people to get CDC positive results from regular/lower-quality labs like LabCorp. As soon as I was on Medicaid 2 yrs ago I was able to get more extensive testing with igenex which not only confirmed "the 3 B's" (borrelia, bartonella & babesia) it was also the 1st time in 7 yrs that showed positive for TBRF. It was SUCH A BIG BLESSING that igenex accepts Medicare!!! And I was happy to report I was doing well with my treatment from my LLNP based off my results, I had an upsetting recent setback and decided to take another igenex test. This time, we were very surprised to find that I had a DIFFERENT type of Bartonella and DIFFERENT type of Babesia showing positive this round. I doubt other labs would have picked that detail up and it will help with my next treatments. However, what I didn't fully comprehend (probably due to brain fog LOL) was that even though I thought I still was covered by Medicare and the plethora of tests we orderd would be covered again, I got a call from igenex to explain that because I have WellCare as additional insurance, Medicare is no longer my "primary insurance" and therefore my tests were NOT covered. So just be mindful of this when ordering your tests folks! The igenex rep was very kind and explained things with compassion to me. It's expensive but it was worth it for more solid answers that will lead to better treatment. Igenex was also nice enough to ask me if I wanted to proceed with the testing before just going ahead and charging me. One day I hope that enough laws will change to allow all insurance to cover these important tests. Overall, I am a two-time, happily satisfied customer and trust them to use them again if ever needed.

WHY IGENEX FOR TICK-BORNE DISEASE TESTING?

CLIA certified in all 50 states
Long track record of success since 1991
Offers testing that is nearly twice as accurate as CDC recommended tests
Tests for all major tick-borne illnesses, including Lyme disease, TBRF, Babesia, Bartonella, and Rickettsia
Utilizes comprehensive testing methods such as PCR, ImmunoBlots, IgXSpot and FISH
Has become a nationwide leader in COVID-19 testing due to a relentless focus on customer satisfaction

TICK-BORNE DISEASE TEST METHODOLOGIES

IGeneX offers a broad range of serological and molecular tests for Tick-Borne diseases. The serological tests include ELISA (Enzyme-linked Immunosorbent Assay), IFA (Indirect Immunofluorescent Assay), Western Blots, ImmunoBlots, IgXSpot, and LDA (Lyme Dot-Blot Assay). The molecular tests include PCR and FISH (Fluorescent In Situ Hybridization).

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IMMUNOBLOTS

The IgM and IgG ImmunoBlot (IB) are qualitative immunoassays in which antibodies are visualized. They are used to determine whether pathogen-specific antibodies are present in patient serum or plasma. These tests are generally more sensitive and specific than the Western Blot, ELISA, and IFA tests.

How it Works

Step 1: IB strip preparation: IB strips are prepared from recombinant proteins of interest. The recombinant proteins are applied to a membrane and cut into strips.

Step 2: Patient serum or plasma is incubated with the IB strip. If specific antibodies to pathogen antigens are present, they will bind to the corresponding antigen bands.

Step 3: After washing off the unbound serum, the strip is incubated with alkaline phosphate-conjugated goat anti-human antibody. Bound antibodies react with BCIP/NBT, a chromogenic substrate. A dark purple colored precipitate develops on the antigen-antibody complexes. Bands are visualized and scored for intensities relative to the positive and negative controls. (See right)

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ImmunoBlot strip example

FISH (FLUORESCENT IN SITU HYBRIDIZATION)

The FISH test provides a significant increase in sensitivity and specificity over standard Giemsa-stained smears for the presence of bacteria, fungi, and intraerythrocytic parasites (piroplasts) in red blood cells.

How it Works

Step 1: A methanol-fixed blood smear is created from a patient’s blood sample.

Step 2: After adding the hybridization buffer with a pathogen-specific probe labeled with a fluorescent dye, the slide is incubated for a short time at 37℃. The pathogen rRNA will hybridize with the pathogen if present in the blood smear.

Step 3: After hybridization is complete, the excess probe is removed by washing with a special wash solution.

Step 4: The smear is dried, and counter-stain is added. The slide is then viewed with a fluorescent microscope; if pathogens are present, the blood smear will fluoresce.

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IGXSPOT

The IgXSpot is an enzyme-linked immunospot assay that detects human T cells reactive to borrelia/pathogen-specific antigens in vitro. It is well documented that both humoral and cellular immune responses develop in borrelia/pathogen infection. The cellular immune response develops much earlier than the humoral response in most patients who are infected with borrelia species. In some patients, sero-conversion from cellular to humoral response does not occur or occurs much later in the disease. In some patients with a chronic form of the disease, the humoral response is poor. Therefore, the IgXSpot test is recommended for detection of very early and/or late borrelia/pathogen infection and in seronegative patient’s whole blood samples.

Principle
ELISPOT is a widely used method for detecting and monitoring cellular immune responses to specific antigens. The IgXSpot assay allows visualization of the secretory product(s) of individual activated or responding cells to borrelia-specific antigens. Each spot that develops in the assay represents a single reactive cell.

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WESTERN BLOTS

The IgG and IgM Western Blots are qualitative immunoassays in which antibodies are visualized. They are used to determine whether pathogen-specific antibodies are present in patient serum or plasma. These tests are generally more sensitive and specific than the ELISA and IFA tests.

How it Works

Step 1: Western Blot strips are prepared from a cell lysate of the pathogen of interest. Briefly, pathogen cell lysate is fractionated on acrylamide gel by electrophoresis.

Step 2: The separated proteins are then transferred from the gel to membranes, which are washed, dried, and sliced into 5 mm strips.

Step 3: Patient serum or plasma is incubated with a Western Blot strip. If specific antibodies to pathogen antigens are present, they will bind to the corresponding antigen bands.

Step 4: After washing off the unbound serum, each strip is incubated with alkaline phosphate-conjugated goat anti-human antibody. Bound antibodies react with BCIP/NBT, a chromogenic substrate. A dark purple colored precipitate develops on the antigen-antibody complexes. Bands are then visualized and scored for intensities relative to the positive and negative controls.

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IFA (INDIRECT IMMUNOFLUORESCENT ASSAY)

IFA indirectly detects pathogen-specific IgG or IgM antibodies in patient serum.

How it Works

Step 1: Patient serum is added onto the slide with fixed pathogens. If pathogen-specific IgG or IgM antibodies are present in the human serum, they will bind to the fixed pathogen on the slide.

Step 2: Unbound serum is removed by washing the slide with a wash buffer, and a fluorescent-labeled anti-human antibody is added.

Step 3: After washing off the excess secondary antibody, the slide is viewed under a fluorescent microscope. If pathogen-specific antibodies are present in the human serum, fixed pathogen on the slide will fluoresce bright green when viewed with a fluorescent microscope.

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LDA (LYME DOT-BLOT ASSAY)

Lyme Dot-Blot Assay (LDA) is a qualitative immunoassay for the direct detection of Borrelia burgdorferi-specific antigens in a patient urine sample using anti-B. burgdorferi antibodies.

If the initial Lyme panel tests on a patient’s blood samples are negative, including PCR, but symptoms for Lyme disease are present, the Lyme Dot-blot assay on urine can be helpful in making the diagnosis.

How it Works

Step 1: The antigens present in the urine sample are immobilized onto a membrane in a Dot-blot format and incubated with anti-B. burgdorferi-specific antibodies.

Step 2: After washing the bound anti-B. burgdorferi-specific antibodies, they are reacted with anti-rabbit IgG, which is visualized by an enzyme/substrate reaction.

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ELISA (ENZYME-LINKED IMMUNOSORBENT ASSAY)

ELISA is a plate-based assay technique designed for detecting and quantifying pathogen-specific antibodies.

How it Works

Step 1: Cell lysate or antigens (including peptides) are immobilized to a solid surface and then complexed with a patient’s anti-pathogen antibody (primary antibody).

Step 2: The pathogen-bound human antibody is captured by an anti-human antibody linked to an enzyme (secondary antibody).

Step 3: Detection is accomplished by assessing the conjugated enzyme activity via incubation with a substrate to produce a measurable product.

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PCR tests are useful for the following reasons:

Enables accurate identification of biochemically unusual strains of pathogen
Facilitates much earlier detection of the microorganism because the assay is independent of the host’s immune response schedule
Allows monitoring of the efficacy of an antibiotic regime
Can be performed on any type of sample: EDTA whole blood, serum, cerebral spinal fluid, synovial fluid, urine, breast milk, tissue biopsy and ticks.
The combination of these factors imparts very high specificity and sensitivity to the test.

PCR

IGeneX offers traditional and real-time PCR Lyme tests and PCR tests for co-infections. The tests were developed in-house from clinical samples using our proprietary hybrid-select method.

The standard PCR test is not always sensitive enough when very few organisms are present in a sample. Furthermore, PCR sensitivity is well known to reduce in the presence of inhibitors. Therefore, IGeneX has developed nucleic-acid-based PCR diagnostic assays that are highly sensitive and specific. Theoretically, these PCR tests can be performed on any type of sample. They offer enhanced performance compared to microbiological, immunological, and amplified tests that are currently available for the detection of microorganisms in test samples.

How it Works

Step 1: Selection hybridization
Specifically removes the “common PCR inhibitors” from the clinical sample while simultaneously selecting and purifying the DNA fragment of interest. This procedure also concentrates the fragment of interest, thereby improving sensitivity.

Step 2: PCR amplification
The purified pathogen DNA fragment of interest is PCR-amplified with pathogen-specific primers. This sequence “hybridizes” or binds specifically to pathogen DNA of interest under predetermined PCR conditions. Therefore, only pathogen-specific DNA is amplified.

Step 3: Detection of amplified products
The PCR-amplified products are transferred and bound to a nitrocellulose membrane. The membrane-bound, PCR-amplified products are hybridized with pathogen-specific probes. Only samples with pathogen-specific DNA hybridize to the probes and give a blue-purple color dot on the membrane.

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WHY IGENEX FOR TICK-BORNE DISEASE TESTING?

CLIA certified in all 50 states
Long track record of success since 1991
Offers testing that is nearly twice as accurate as CDC recommended tests
Tests for all major tick-borne illnesses, including Lyme disease, TBRF, Babesia, Bartonella, and Rickettsia
Utilizes comprehensive testing methods such as PCR, ImmunoBlots, IgXSpot and FISH
Has become a nationwide leader in COVID-19 testing due to a relentless focus on customer satisfaction